Schiff bases derived from 4-amino-N-substituted benzenesulfonamide: synthesis, spectral characterisation and MIC evaluation
نویسندگان
چکیده
ABSTRACT. The present study is aimed to synthesise Schiff bases from sulfathiazole/ sulfamethoxazole/ sulfadimidine with 2-hydroxybenzaldehyde. synthesized were characterized by analytical data, IR, 1H-NMR, 13C-NMR, UV-Vis spectra, mass spectra and screened for antibacterial activity against gram positive bacteria Staphylococcus aureus negative Salmonella typhiand antifungal Candida albicans Mucor disc diffusion method. Zone of inhibition indicated that the base possessed highly potent antimicrobial when compared sulpha drugs.
 
 KEY WORDS: 4-Amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, 4-amino-N-(5-methylisoxazol-3-yl)-benzenesulfonamide, 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide, 2-hydroxybenzaldehyde, activity
 Bull. Chem. Soc. Ethiop. 2021, 35(2), 435-448. DOI: https://dx.doi.org/10.4314/bcse.v35i2.16
منابع مشابه
Synthesis and Characterisation of new Heterocyclic Schiff base ligand derived from 4-Amino Antipyrine
A new heterocyclic Schiff base ligands and their complexes have been synthesized from 4-aminoantipyrine, thiophene-2-Carboxaldehyde and 2-amino benzoic acid. The ligands and its transition metal complexes of Cu (II), Co (II), Ni (II) and Zn (II) are characterized by UV, FTIR NMR and Mass studies. The antibacterial and antifungal activity of the ligands and the metal complexes were tested.
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Article history: Received 15 April 2014 Received in revised form 22 May 2014 Accepted 25 October 2014 Available online 10 November 2014
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ژورنال
عنوان ژورنال: Bulletin of The Chemical Society of Ethiopia
سال: 2021
ISSN: ['1011-3924', '1726-801X']
DOI: https://doi.org/10.4314/bcse.v35i2.16